As capital rotates toward select U.S.-based innovation stories heading into early 2026, a group of small-cap names across regulated fintech, wireless infrastructure, immuno-oncology, and medical technology is drawing increased investor attention. High Roller Technologies (NYSE: ROLR), SurgePays (NASDAQ: SURG), ImmunityBio (NASDAQ: IBRX), and ENDRA Life Sciences (NASDAQ: NDRA) each represent distinct sector-driven catalysts that align with current macro themes, regulatory momentum, and platform-scale potential.
High Roller Technologies (NYSE: ROLR)
High Roller Technologies announced a binding strategic partnership with Crypto.com, marking a major expansion beyond traditional iGaming into regulated, event-based prediction markets in the United States. Under the LOI, prediction contracts will be offered by Crypto.com | Derivatives North America, a CFTC-registered exchange and clearinghouse, and distributed through HighRoller.com. The platform will allow users to trade outcomes across finance, sports, and entertainment, with a targeted Q1 2026 launch. Management highlighted the opportunity to pair High Roller’s premium digital distribution with a category analysts estimate could exceed $1 trillion in annual U.S. trading volume, positioning the company to participate in one of the fastest-growing regulated online engagement markets.
SurgePays (NASDAQ: SURG)
SurgePays is emerging as a differentiated small-cap technology platform at the intersection of wireless connectivity and fintech, serving the large and growing prepaid and underbanked consumer market. The company operates a vertically integrated model spanning subsidized Lifeline wireless, prepaid services, embedded fintech payments, and carrier-grade MVNE infrastructure, supported by a nationwide retail distribution network of more than 9,000 locations. With a cash-generative Lifeline foundation, AT&T-enabled MVNE validation, and expanding high-margin platform layers including ClearLine retail media and ProgramBenefits lead monetization, SurgePays is transitioning from a transactional prepaid provider into a recurring, infrastructure-driven business, driving increased investor attention as its revenue mix shifts toward higher-quality, scalable streams.
ImmunityBio (NASDAQ: IBRX)
ImmunityBio captured strong market interest after announcing that the Saudi Food and Drug Authority granted accelerated approval to ANKTIVA® (nogapendekin alfa inbakicept) in combination with immune checkpoint inhibitors for metastatic non-small cell lung cancer. The decision marks the first global approval of a subcutaneously administered IL-15 receptor superagonist and the first approved chemotherapy-free immunotherapy activating both NK and killer T cells. Supported by data from the QUILT-3.055 and QUILT-2.023 studies, the approval aligns with ImmunityBio’s strategy to expand across the Middle East, including a regional Saudi office and commercial partner BioPharma Cigalah. Shares closed up 8.88% on more than 32 million shares traded, reflecting heightened investor interest following the regulatory milestone.
Brand Engagement Network (NASDAQ: BNAI)
Brand Engagement Networkis emerging as a differentiated small-cap AI and customer engagement platform, focused on transforming how enterprises interact with consumers across digital and physical touchpoints. The company leverages proprietary conversational AI, data analytics, and automation tools to deliver personalized, real-time brand interactions for clients in sectors including retail, media, automotive, and financial services. As enterprises increasingly prioritize AI-driven customer experience, cost efficiency, and scalable engagement solutions, Brand Engagement Network is positioning itself as a next-generation provider at the intersection of artificial intelligence, digital marketing, and customer experience technology, with growing relevance as AI adoption accelerates across corporate America.
ENDRA Life Sciences (NASDAQ: NDRA)
ENDRA Life Sciences is positioning itself as a forward-looking small-cap medtech innovator by pairing its breakthrough TAEUS® liver imaging platform with a next-generation treasury strategy focused on capital efficiency. TAEUS® enables real-time, non-invasive measurement of liver fat at the point of care, addressing steatotic liver disease (SLD) and MASH—conditions affecting more than two billion people globally. Recent clinical data showing strong alignment with MRI-PDFF at key decision thresholds strengthens TAEUS®’s potential role in routine clinical use and pharmaceutical trials, particularly as demand accelerates alongside the expanding GLP-1 therapy market. By combining clinical momentum with a disciplined, non-dilutive financial approach, ENDRA is aligning innovation with long-term shareholder strategy.
Bottom Line
As 2026 approaches, ROLR, SURG, IBRX, BNAI, and NDRA reflect how small-cap companies can align with macro trends, regulatory tailwinds, and scalable platforms across diverse sectors. From regulated prediction markets and wireless-fintech infrastructure to immunotherapy breakthroughs and next-generation diagnostics, this group represents a MAGA SmallCaps watchlist where execution and catalysts—not speculation—are driving renewed investor focus.
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